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Sleep is one of the most important activities of our lives. Ideally you should get 7-9 hours of sleep each night without the need for an alarm clock to wake up. Your sleep pattern should be consistent in terms of bed time and wake up time. Your sleep should be of high quality and restorative to make you feel completely rested when awakening.
Studies have shown that people with inadequate sleep have a ten times higher probability to experience depression and 17 times higher probability to experience anxiety. Research also suggest that poor sleep elevates the risk for suicidal behavior, independent of other mental health problems. Inadequate sleep has also been linked to a higher probability of developing neurodegenerative diseases and other serious health conditions.
Inadequate and poor quality sleep will disrupt or biological clock, or circadian rhythm, and therefore affect mental health. A sleep-deprived brain has a compromised ability to make emotional judgements, process information and perform logic reasoning, or problem solving. A dysregulated circadian system will also affect the immune system, detoxification, cell repair and other essential processes.
HYPNOPHOREA is formulated with multiple high quality natural products that have scientifically proven sleep-promoting activities:
Melatonin
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Supports healthy sleep patterns, immune function, and antioxidant support (256,257, 258).
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Supports healthy circadian rhythms, and improves the onset, duration, and quality of sleep.
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Supports immune function via improved free radical scavenging capacity (258).
Valerian Root
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Reduces stress, enhances sleep, and improves mood (244,245).
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Enhances positive mood and sleep via regulated gamma‐aminobutyric acid receptor A (GABAA) activity (receptor which controls sleep) (244, 245).
Chamomile
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Supports healthy sleep, relaxation, reduced anxiety, and antioxidant support (251,252,253).
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Supports antioxidant function due to high levels of quercetin (flavonoid antioxidant) (251,252,253).
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Supports sleep via increases in parasympathetic (relaxation mode) activity, increased benzodiazepine-like hypnotic activity (sleep inducer), and attachment to GABA receptors (251,252,253).
Lemon Balm
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Supports healthy sleep, relaxation, reduced anxiety, and antioxidant support (254,255).
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Supports antioxidant function via ability to scavenge free radicals, reduce oxidative stress, increased glutathione production (master antioxidant) combat DNA damage (254,225).
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Supports relaxed sleep via enhanced REM cycles reduced stress at bedtime (254,225).
Passion Flower
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Reduces stress, enhances sleep, and improved mood (248).
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Enhances positive mood and sleep via regulated gamma‐aminobutyric acid receptor A (GABAA) activity (receptor which controls sleep) (248).
Hops
Combats depression, anxiety, reduces triglycerides and supports a positive mood (246,247).
St. John’s Wort
Combats depression and supports a positive mood (249,250).
Skullcap
Supports calming mood and relaxation (1149).
Ashwagandha
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Supports cardiovascular, hormonal, immune, healthy weight loss, mood, and optimized sleep (82,83).
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Reduces stress hormone cortisol resulting in improved body composition, sex hormone profile, and mood (82,83).
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Improves exercise performance via increased V02 max, muscular endurance, muscle hypertrophy (muscle growth), and decreased muscular fatigue (83).
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Improves quality of sleep by enhancing sleep recovery, reducing plasma cortisol concentrations, and enhancing REM sleep cycles (83).
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Supports hormonal and immune health via reduced production of inflammatory molecules (reactive oxygen species) and simultaneous increases in sex hormones (84).
Goji Berry
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Supports immune health, vision health, immune health, and aids as a neuroprotective agent (261,262).
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Supports immune function via carotenoid and polyphenolic free radical scavenging capabilities, reduced DNA damage, and reduced inflammatory cytokines (261).
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Supports vision health via ocular neuroprotective effects zeaxanthin content (found in goji berry) (262).
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Increases neuronal protection with potent ameliorative effects on neuronal oxidative stress, inflammation, apoptosis and neuronal cell death (262).
L-Tryptophan
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Decreases anxiety, supports positive mood, supports gut brain axis, and an improved sleep cycle (259,260).
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Decreases anxiety via increases in 5 HTP (259, 260).
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Improves circadian rhythm via increased natural melatonin production (259,260).
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Supports gut brain axis via natural increased production of serotonin in gut neurons (260).
GABA
Supports relaxation, positive mood, increased memory, reduced anxiety, blood sugar regulation, and increased growth hormone production (102).
L-Taurine
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Supports hydration, increased energy, antioxidant function, and increases fat metabolism during aerobic exercise (242,243).
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Supports antioxidant function via combating reactive oxygen species (243).
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Increases fat metabolism during exercise via enhanced mitochondrial fatty acid oxidation (cells using fat as fuel) (242).
L-Theanine
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Unique non-protein amino acid found in green tea (Camellia sinensis) (54).
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Supports mood, mental clarity, and cognitive health, memory, and is a natural anti-depressant/neuroprotective agent (54).
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Reduces the neuropsychiatric side effects of chronic adolescent THC exposure (55).
Inositol
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Supports liver detoxification, combats metabolic syndrome, and aids as an antioxidant (221).
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Combats metabolic syndrome via reduced levels of triglycerides, total- and LDL-cholesterol (221).
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Supports antioxidant function via reduced levels of reactive oxygen species and inflammatory markers (interleukin 6) (222).
5-HTP
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Supports healthy sleep patterns, mood, reduced anxiety, and supports the gut brain axis (261).
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Supports healthy sleep patterns via enhanced circadian rhythm and increased natural melatonin production (261).
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Supports gut brain axis via natural increased production of serotonin (neurotransmitter) in gut neurons (260, 261).
Check out our Lab News page for updates on newly discovered health benefits of the various active ingredients in our products. Science is continuously advancing with new studies and discoveries.
Our formula
1. Uses third party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility.
2. Uses high quality nutraceuticals in an effective evidence based and efficaciously dosed formula.
Other formulas on the market
1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third party tested have been removed by FDA due to high levels of heavy metals.
2. Uses cheap sources of nutraceuticals that contain high amounts of fillers, heavy metals, and is formulated without evidence based dosages.
HYPNOPHOREA is manufactured in FDA Registered and GMP Certified facilities, and is fulfilled for Longevity Technologies by Rocktomic Labs.
Scientific Literature
256. Xie, Z., Chen, F., Li, W. A., Geng, X., Li, C., Meng, X., Feng, Y., Liu, W., & Yu, F. (2017). A review of sleep disorders and melatonin. Neurological research, 39(6), 559–565. https://doi.org/10.1080/01616412.2017.1315864
257. Vural, E. M., van Munster, B. C., & de Rooij, S. E. (2014). Optimal dosages for melatonin supplementation therapy in older adults: a systematic review of current literature. Drugs & aging, 31(6), 441–451. https://doi.org/10.1007/s40266-014-0178-0
258. Zarezadeh, M., Khorshidi, M., Emami, M., Janmohammadi, P., Kord-Varkaneh, H., Mousavi, S. M., Mohammed, S. H., Saedisomeolia, A., & Alizadeh, S. (2020). Melatonin supplementation and pro-inflammatory mediators: a systematic review and meta-analysis of clinical trials. European journal of nutrition, 59(5), 1803–1813. https://doi.org/10.1007/s00394-019-02123-0
244. Bent S, Padula A, Moore D, Patterson M, Mehling W. Valerian for sleep: a systematic review and meta-analysis. Am J Med. 2006 Dec;119(12):1005-12. doi: 10.1016/j.amjmed.2006.02.026. PMID: 17145239; PMCID: PMC4394901.
245. Shinjyo N, Waddell G, Green J. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20967323. doi: 10.1177/2515690X20967323. PMID: 33086877; PMCID: PMC7585905.
251. Chang SM, Chen CH. Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial. J Adv Nurs. 2016 Feb;72(2):306-15. doi: 10.1111/jan.12836. Epub 2015 Oct 20. PMID: 26483209.
252. McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother Res. 2006 Jul;20(7):519-30. doi: 10.1002/ptr.1900. PMID: 16628544.
253. Srivastava JK, Shankar E, Gupta S. Chamomile: A herbal medicine of the past with bright future. Mol Med Rep. 2010 Nov 1;3(6):895-901. doi: 10.3892/mmr.2010.377. PMID: 21132119; PMCID: PMC2995283.
254. Miraj S, Rafieian-Kopaei, Kiani S. Melissa officinalis L: A Review Study With an Antioxidant Prospective. J Evid Based Complementary Altern Med. 2017 Jul;22(3):385-394. doi: 10.1177/2156587216663433. Epub 2016 Sep 11. PMID: 27620926; PMCID: PMC5871149.
255. Taavoni S, Nazem Ekbatani N, Haghani H. Valerian/lemon balm use for sleep disorders during menopause. Complement Ther Clin Pract. 2013 Nov;19(4):193-6. doi: 10.1016/j.ctcp.2013.07.002. Epub 2013 Sep 10. PMID: 24199972.
248. Janda K, Wojtkowska K, Jakubczyk K, Antoniewicz J, Skonieczna-Żydecka K. Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. Nutrients. 2020 Dec 19;12(12):3894. doi: 10.3390/nu12123894. PMID: 33352740; PMCID: PMC7766837.
249. Ng QX, Venkatanarayanan N, Ho CY. Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. J Affect Disord. 2017 Mar 1;210:211-221. doi: 10.1016/j.jad.2016.12.048. Epub 2017 Jan 3. PMID: 28064110.
250. Apaydin, E. A., Maher, A. R., Shanman, R., Booth, M. S., Miles, J. N., Sorbero, M. E., & Hempel, S. (2016). A systematic review of St. John's wort for major depressive disorder. Systematic reviews, 5(1), 148. https://doi.org/10.1186/s13643-016-0325-2
246. Kyrou I, Christou A, Panagiotakos D, Stefanaki C, Skenderi K, Katsana K, Tsigos C. Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study. Hormones (Athens). 2017 Apr;16(2):171-180. doi: 10.14310/horm.2002.1738. PMID: 28742505.
247. Hamm AK, Manter DK, Kirkwood JS, Wolfe LM, Cox-York K, Weir TL. The Effect of Hops (Humulus lupulusL.) Extract Supplementation on Weight Gain, Adiposity and Intestinal Function in Ovariectomized Mice. Nutrients. 2019 Dec 7;11(12):3004. doi: 10.3390/nu11123004. PMID: 31817899; PMCID: PMC6950254.
82. Langade, D., Kanchi, S., Salve, J., Debnath, K., & Ambegaokar, D. (2019). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus, 11(9), e5797. https://doi.org/10.7759/cureus.5797
83. Bonilla, D. A., Moreno, Y., Gho, C., Petro, J. L., Odriozola-Martínez, A., & Kreider, R. B. (2021). Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis. Journal of functional morphology and kinesiology, 6(1), 20. https://doi.org/10.3390/jfmk6010020
259. Kikuchi, A. M., Tanabe, A., & Iwahori, Y. (2021). A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning. Journal of dietary supplements, 18(3), 316–333. https://doi.org/10.1080/19390211.2020.1746725
260. Jenkins, T. A., Nguyen, J. C., Polglaze, K. E., & Bertrand, P. P. (2016). Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients, 8(1), 56. https://doi.org/10.3390/nu8010056
102. Powers M. (2012). GABA supplementation and growth hormone response. Medicine and sport science, 59, 36–46. https://doi.org/10.1159/000341944
242. Waldron, M., Patterson, S. D., Tallent, J., & Jeffries, O. (2018). The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis. Sports medicine (Auckland, N.Z.), 48(5), 1247–1253. https://doi.org/10.1007/s40279-018-0896-2
243.Ahmadian, M., Roshan, V. D., Aslani, E., & Stannard, S. R. (2017). Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure. Therapeutic advances in cardiovascular disease, 11(7), 185–194. https://doi.org/10.1177/1753944717711138
54. Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 11(10), 2362. https://doi.org/10.3390/nu11102362
55. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
221. Tabrizi R, Ostadmohammadi V, Lankarani KB, Peymani P, Akbari M, Kolahdooz F, Asemi Z. The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. 2018 May 24;17(1):123. doi: 10.1186/s12944-018-0779-4. PMID: 29793496; PMCID: PMC5968598
222. Formoso G, Baldassarre MPA, Ginestra F, Carlucci MA, Bucci I, Consoli A. Inositol and antioxidant supplementation: Safety and efficacy in pregnancy. Diabetes Metab Res Rev. 2019 Jul;35(5):e3154. doi: 10.1002/dmrr.3154. Epub 2019 Apr 10. PMID: 30889626; PMCID: PMC6617769.
261. Turner, E. H., Loftis, J. M., & Blackwell, A. D. (2006). Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacology & therapeutics, 109(3), 325–338. https://doi.org/10.1016/j.pharmthera.2005.06.004
260. Jenkins, T. A., Nguyen, J. C., Polglaze, K. E., & Bertrand, P. P. (2016). Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients, 8(1), 56. https://doi.org/10.3390/nu8010056
1149. Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Med Sci Monit. 2009 Nov;15(11):RA256-62. PMID: 19865069.
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