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PROSERENO - Calmness formula is designed to support reduced anxiety, healthy sleep cycles (circadian rhythm), relaxation, reduce mental fatigue and improve mood. Our product is synthesized utilizing the latest scientific research and formulated with high quality ingredients.
 
[PROSERENO: -pro- (Latin meaning “forward”, forward movement”); sereno from -serenus- (Latin meaning “clear”, “unclouded”, “peaceful”)]

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Stress and anxiety are some of the most potent health-span suppressors, and responsible for many adverse health conditions, including cardiovascular diseases, cancer, diabetes, asthma, insomnia, gastrointestinal problems, chronic pain, autoimmune conditions, mental health issues such as depression, neurodegenerative diseases such as Alzheimer's, and accelerated aging leading to premature death.

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Today's rapid information flow and fast pace of life has dramatically increased pressures placed on us, both in our personal and professional lives. The average adult makes about 35,000 or more, decisions per day, and many of them are hard because of uncertain risk and reward outcomes. These complexities and demands of life all result in increased anxiety and stress levels that need to be managed

Be proactive and turn down your stress level with PROSERENO. Reclaim your serenity and health.

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PROSERENO contains several neuromodulatory active ingredients with calming and relaxing effects:

Rhodiola rosea
Rhodiola rosea is a perennial flowering plant in the family Crassulaceae. Rhodiola is used for increasing energy, stamina, strength and mental capacity; and as a so-called “adaptogen” to help the body adapt to and resist physical, chemical, and environmental stress (14).

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Chamomile

  • Supports healthy sleep, relaxation, reduced anxiety, and antioxidant support (251,252,253).

  • Supports antioxidant function due to high levels of quercetin (flavonoid antioxidant) (251,252,253).

  • Supports sleep via increases in parasympathetic (relaxation mode) activity, increased benzodiazepine-like hypnotic activity (sleep inducer), and attachment to GABA receptors (251,252,253).

Lemon Balm

  • Supports healthy sleep, relaxation, reduced anxiety, and antioxidant support (254,255).

  • Supports antioxidant function via ability to scavenge free radicals, reduce oxidative stress, increased glutathione production (master antioxidant) combat DNA damage (254,225).

  • Supports relaxed sleep via enhanced REM cycles reduced stress at bedtime (254,225).

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Passion Flower

  • Reduces stress, enhances sleep, and improved mood (248)

  • Enhances positive mood and sleep via regulated gamma‐aminobutyric acid receptor A (GABAA) activity (receptor which controls sleep) (248).

Munica Pruriens

  • Supports blood sugar regulation, sexual enhancement, aids an anti-inflammatory agent, combats neurodegenerative disease, and supports antimicrobial activity (128).

  • Supports anti-aging, rheumatoid, arthritis, diabetes, male infertility, and nervous disorders (128).

  • Supports male sexual health via increased sperm motility and increased free testosterone (128). 

  • Combats neurodegenerative disease via stimulation of dopaminergic neurons (129).

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St. John’s Wort

  • Combats depression and supports positive mood (249,250).

GABA
Supports relaxation, positive mood, increased memory, reduced anxiety, blood sugar regulation, and increased growth hormone production (102).

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Skullcap

  • Supports calming mood and relaxation.

L-Theanine

  • Unique non-protein amino acid found in green tea (Camellia sinensis) (54).

  • Supports mood, mental clarity, and cognitive health, memory, and is a natural anti-depressant/neuroprotective agent (54).

  • Aids as an antidepressant due to partial antagonism for the

  • Reduces the neuropsychiatric side effects of chronic adolescent THC exposure (55).

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Ashwagandha

  • Supports cardiovascular, hormonal, immune, healthy weight loss, mood, and optimized sleep (82,83).

  • Reduces stress hormone cortisol resulting in improved body composition, sex hormone profile, and mood (82,83).

  • Improves exercise performance via increased V02 max, muscular endurance, muscle hypertrophy (muscle growth), and decreased muscular fatigue (83). 

  • Improves quality of sleep by enhancing sleep recovery, reducing plasma cortisol concentrations, and enhancing REM sleep cycles (83).

  • Supports hormonal and immune health via reduced production of inflammatory molecules (reactive oxygen species) and simultaneous increases in sex hormones (83).

Bacopa

  • Supports cognitive function, memory, alertness, and aids as an anti-stress agent (57).

  • May combat inflammatory conditions such as asthma, bronchitis, dropsy, and rheumatism (56,59).

  • Bacopa has been shown to have anti-inflammatory effects on macrophages (immune cells) and inhibits the release of IL-6 and TNF-α (inflammatory markers) from monocytes (immune cells) (58,59,).

  • Promising candidate for the development of novel therapeutics that target neuroinflammation and have the potential for treating a wide range of CNS disorders including Alzheimer's disease, depression, and schizophrenia (59).

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Magnolia

  • Supports antioxidant function, positive mood, and aids a neuroprotective agent (263,264).

  • Supports relaxed shorten sleep latency and regulated gamma‐aminobutyric acid receptor A (GABAA) activity (receptor which controls sleep) (263,264).

Griffonia Seed Ext -5-HTP

  • Supports healthy sleep patterns, mood, reduced anxiety, and supports the gut brain axis (261).

  • Supports healthy sleep patterns via enhanced circadian rhythm and increased natural melatonin production (261).

  • Supports gut brain axis via natural increased production of serotonin (neurotransmitter) in gut neurons (260, 261).

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Valarian Root
Reduces stress, enhances sleep, and improved mood (244,245).

Check out our Lab News page for updates on newly discovered health benefits of the various active ingredients in our products. Science is continuously advancing with new studies and discoveries.

Fertile, Eyes, Visual System, Vision, Blindness, Auditory System, Ears, Smell, Nose, Taste, Touch, Tactile, Balance, Cardiovascular Health, Neuropathy, Cancer, Anti-Cancer, Heart, Heart Attack, Strong Nails, Shiny Hair, Immune Boosted, Immunity, Joint Support, Adaptogen, Calming, Anti-Stress, Stress Relief, Cryotherapy, Thermotherapy, Cryogenics, Heat Therapy, Cold Therapy, Light Therapy, Oxygen Therapy, Halotherapy, Stem Cells, Stem Cell Therapy, Electromagnetic Therapy, HGH, Human Growth Factor, Growth Hormone Testosterone, Improve Memory, Improve Focus, Boost Cognition, Improve Cognitive Functions, Prebiotics, Probiotics, Fiber, Curcumin, Turmeric, Elderberry, Berberine, Ashwagandha, Ginger, Omega-3, Ubiquinol, Cordyceps , Lions Mane, Turkey Tail, Chaga, Shiitake, Maitake, Reishi, Mushrooms, Nicotinamide, NAD, Resveratrol, Zinc, Acai, Lycopene, Chlorella, Psyllium, Maca, Saw Palmetto, Bacopa, Ginseng, Astragalus, Cayenne Pepper, Tribulus, Licorice, L-Arginine, Creatine, Nitric Oxide
Bio-Hack, Longevity, Lifespan, Long Life, Health-Span, Health-Span Extension, Aging, Anti-Aging, Reverse Aging, Aging Reversal, Healthy Aging, , Natural, Old, Senior, Retired, Retirement, Aged, Anti-Wrinkle, Lifespan Extension, Endocrine System, Hormonal System, Immune System, Immune Defense, Digestive System, Digestion, Intestinal System, Stomach, Urinary System, Kidney, Kidney Stones, Prostate Health, Reproductive System, Fertility, Fertile, Muscular System, Skeletal System, Bones, Osteoporosis, Skin, Hair, Nails, Sensory System, Cordyceps , Lions Mane, Turkey Tail, Chaga, Shiitake, Maitake, Reishi, Mushrooms, Nicotinamide, NAD, Resveratrol, Zinc, Acai, Lycopene, Chlorella, Psyllium, Maca, Saw Palmetto, Bacopa, Ginseng, Astragalus, Cayenne Pepper, Tribulus, Licorice, L-Arginine, Creatine, Nitric Oxide, Papain, Green Tea, Bilberry, Huperzine, Grape Seeds, Garlic, Fish Oil, Biotin, Folic Acid, Calcium, Iron, Magnesium, Selenium, Chromium, Copper, Iron, Manganese, Chamomile, GABA
Young, Health, Well, Wellness, Rejuvenating, Healthy, Vigor, Husky, Firm, Firm Skin, Clear Skin, Memory, Intelligent, Clear Mind, Brain Fog, Dementia, Alzheimer’s, Smooth Skin, Firm Body, Slim, Skinny, Stamina, Strength, Obesity, Anti-Obesity, Obese, Weight Loss, Diet, Healthy Diet, Mediterranean Diet, Youth, Youthful, Euphoria, Virile, Potent, Toned, Toned Body, Muscular, Fit, Fitness, Restored, Active, Tough, Tough Body, Hardy, Robust, Well-Being, Athletic, Antioxidant, Anti-Inflammatory, Telomere, Telomerase, Autophagy, Senescence, Sirtuin, Epigenetic, Detox, Cleansing, Nutraceutical, Supplements, Nutrients, Nutritious, Vitamins, Herbal, Herbs, Natural Medicine, Ethnomedicine, Nervous System, Circulatory System, Respiratory System, Papain, Green Tea, Bilberry, Olive Oil, Coconut Oil, Huperzine, Grape Seeds, Garlic, Fish Oil, Biotin, Folic Acid, Calcium, Iron, Magnesium, Selenium, Chromium, Copper, Iron, Manganese, Chamomile, St. John’s Wort, GABA, Lemon Balm, Skullcap, Valarian Root

Our formula
1. Uses third party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility.
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2. Uses high quality nutraceuticals in an effective evidence based and efficaciously dosed formula.

Other formulas on the market
1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third party tested have been removed by FDA due to high levels of heavy metals.
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2. Uses cheap sources of nutraceuticals that contain high amounts of fillers, heavy metals, and in formulated without evidence based dosages.

Bio-Hack, Longevity, Lifespan, Long Life, Health-Span, Health-Span Extension, Aging, Anti-Aging, Reverse Aging, Aging Reversal, Healthy Aging, , Natural, Old, Senior, Retired, Retirement, Aged, Anti-Wrinkle, Lifespan Extension, Endocrine System, Hormonal System, Immune System, Immune Defense, Digestive System, Digestion, Intestinal System, Stomach, Urinary System, Kidney, Kidney Stones, Prostate Health, Reproductive System, Fertility, Fertile, Muscular System, Skeletal System, Bones, Osteoporosis, Skin, Hair, Nails, Sensory System, Cordyceps , Lions Mane, Turkey Tail, Chaga, Shiitake, Maitake, Reishi, Mushrooms, Nicotinamide, NAD, Resveratrol, Zinc, Acai, Lycopene, Chlorella, Psyllium, Maca, Saw Palmetto, Bacopa, Ginseng, Astragalus, Cayenne Pepper, Tribulus, Licorice, L-Arginine, Creatine, Nitric Oxide, Papain, Green Tea, Bilberry, Huperzine, Grape Seeds, Garlic, Fish Oil, Biotin, Folic Acid, Calcium, Iron, Magnesium, Selenium, Chromium, Copper, Iron, Manganese, Chamomile, GABA
Fertile, Eyes, Visual System, Vision, Blindness, Auditory System, Ears, Smell, Nose, Taste, Touch, Tactile, Balance, Cardiovascular Health, Neuropathy, Cancer, Anti-Cancer, Heart, Heart Attack, Strong Nails, Shiny Hair, Immune Boosted, Immunity, Joint Support, Adaptogen, Calming, Anti-Stress, Stress Relief, Cryotherapy, Thermotherapy, Cryogenics, Heat Therapy, Cold Therapy, Light Therapy, Oxygen Therapy, Halotherapy, Stem Cells, Stem Cell Therapy, Electromagnetic Therapy, HGH, Human Growth Factor, Growth Hormone Testosterone, Improve Memory, Improve Focus, Boost Cognition, Improve Cognitive Functions, Prebiotics, Probiotics, Fiber, Curcumin, Turmeric, Elderberry, Berberine, Ashwagandha, Ginger, Omega-3, Ubiquinol, Cordyceps , Lions Mane, Turkey Tail, Chaga, Shiitake, Maitake, Reishi, Mushrooms, Nicotinamide, NAD, Resveratrol, Zinc, Acai, Lycopene, Chlorella, Psyllium, Maca, Saw Palmetto, Bacopa, Ginseng, Astragalus, Cayenne Pepper, Tribulus, Licorice, L-Arginine, Creatine, Nitric Oxide

PROSERENO  is manufactured in FDA Registered and GMP Certified facilities, and is fulfilled for Longevity Technologies by Rocktomic Labs.

Scientific Literature
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251. Chang SM, Chen CH. Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial. J Adv Nurs. 2016 Feb;72(2):306-15. doi: 10.1111/jan.12836. Epub 2015 Oct 20. PMID: 26483209.
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253. Srivastava JK, Shankar E, Gupta S. Chamomile: A herbal medicine of the past with bright future. Mol Med Rep. 2010 Nov 1;3(6):895-901. doi: 10.3892/mmr.2010.377. PMID: 21132119; PMCID: PMC2995283.
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249. Ng QX, Venkatanarayanan N, Ho CY. Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. J Affect Disord. 2017 Mar 1;210:211-221. doi: 10.1016/j.jad.2016.12.048. Epub 2017 Jan 3. PMID: 28064110.
250. Apaydin, E. A., Maher, A. R., Shanman, R., Booth, M. S., Miles, J. N., Sorbero, M. E., & Hempel, S. (2016). A systematic review of St. John's wort for major depressive disorder. Systematic reviews, 5(1), 148. https://doi.org/10.1186/s13643-016-0325-2
128. Pathania, R., Chawla, P., Khan, H., Kaushik, R., & Khan, M. A. (2020). An assessment of potential nutritive and medicinal properties of Mucuna pruriens: a natural food legume. 3 Biotech, 10(6), 261. https://doi.org/10.1007/s13205-020-02253-x
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54. Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 11(10), 2362. https://doi.org/10.3390/nu11102362
55. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
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